Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.4K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.4K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.9K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.9K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.9K
Allergic Reactions02:06

Allergic Reactions

32.6K
Overview
32.6K
Inflammation01:38

Inflammation

62.6K
Overview
62.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Milk-derived extracellular vesicles loaded with miR-146a-5p as a novel therapeutic strategy for allergic airway inflammation.

Molecular therapy. Nucleic acids·2026
Same author

Angiogenin mediates cell-cell fusion as a mitochondrial RNA processing enzyme.

Bone research·2026
Same author

Mesenchymal stem cell-derived small extracellular vesicles promote mitochondrial repair of dopaminergic neurons via Homer protein homolog 3 in Parkinson's disease.

Neural regeneration research·2026
Same author

Epithelial Fucosylation Drives Airway Barrier Dysfunction and Allergic Inflammation via a FUT1 -CDH12 Axis.

Allergy·2026
Same author

The SPRR2A-CSTA axis drives IL-17A-induced squamous metaplasia and steroid resistance in allergic rhinitis.

The Journal of allergy and clinical immunology·2026
Same author

Corrigendum to "PPAR-γ suppresses macrophage senescence and allergic airway inflammation through controlling lipid metabolic pathways" [EBioMedicine 126 (2026) 106226].

EBioMedicine·2026

Related Experiment Video

Updated: Feb 20, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.6K

Macrophage polarization and allergic asthma.

Arjun Saradna1, Danh C Do2, Shruthi Kumar3

  • 1Division Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Md; Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY.

Translational Research : the Journal of Laboratory and Clinical Medicine
|October 26, 2017
PubMed
Summary

Macrophage polarization significantly impacts allergic asthma development. Targeting epigenetic regulation of macrophage phenotypes offers potential new therapeutic strategies for asthma and other allergic diseases.

More Related Videos

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.2K
Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
07:45

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Published on: November 28, 2015

36.6K

Related Experiment Videos

Last Updated: Feb 20, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.6K
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

8.2K
Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
07:45

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis

Published on: November 28, 2015

36.6K

Area of Science:

  • Immunology
  • Molecular Biology
  • Pulmonology

Background:

  • Allergic asthma involves airway inflammation and hyperresponsiveness.
  • Macrophage polarization into M1 and M2 phenotypes is crucial in asthma pathogenesis.
  • Regulation of macrophage polarization involves complex interactions of cytokines, chemokines, and cells.

Purpose of the Study:

  • To review the role of macrophage polarization in allergic asthma.
  • To explore the epigenetic mechanisms regulating macrophage polarization in asthma.
  • To identify potential therapeutic targets for asthma treatment.

Main Methods:

  • Review of existing literature on macrophage biology and asthma.
  • Analysis of signaling pathways and epigenetic modifications (microRNAs, DNA methylation, histone modification) in macrophage polarization.
  • Discussion of therapeutic interventions targeting macrophage regulators.

Main Results:

  • Macrophage polarization is intricately linked to asthma development and severity.
  • Epigenetic changes play a critical role in modulating macrophage function and polarization.
  • Specific molecular regulators of macrophage polarization are potential therapeutic targets.

Conclusions:

  • Modulating macrophage polarization through epigenetic interventions may offer novel therapeutic avenues for allergic asthma.
  • Understanding the epigenetic landscape of macrophage polarization is key to developing effective asthma treatments.
  • Targeting macrophage phenotypes presents a promising strategy for managing allergic diseases.