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Understanding and targeting resistance mechanisms in NSCLC

Julia Rotow1,2, Trever G Bivona1,2,3

  • 1Department of Medicine, Division of Hematology and Oncology, University of California San Francisco, 505 Parnassus Avenue, Box 1270, San Francisco, California 94143, USA.

Nature Reviews. Cancer
|October 26, 2017
PubMed
Summary

Targeted therapies for non-small-cell lung cancer (NSCLC) show promise but face resistance. Understanding on-target and off-target resistance mechanisms, including tumor microenvironment interactions, is key to improving patient outcomes.

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