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Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymers02:34

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Characteristics and Nomenclature of Homopolymers01:00

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Polymers that are made up of identical monomer units are called homopolymers. Only one repeating unit is involved in the construction of the homopolymer structure. For example, as depicted in Figure 1, polypropylene is a homopolymer constituted of propylene monomers. Here, the only repeating unit in the polymer chain is propylene.
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Polymer Classification: Architecture01:14

Polymer Classification: Architecture

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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Characteristics and Nomenclature of Copolymers01:24

Characteristics and Nomenclature of Copolymers

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Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

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Polypeptoid polymers: Synthesis, characterization, and properties.

Brandon A Chan1, Sunting Xuan1, Ang Li1

  • 1Department of Chemistry and Macromolecular Studies Group, Louisiana State University, Baton Rouge, 70803, Los Angeles.

Biopolymers
|October 26, 2017
PubMed
Summary
This summary is machine-generated.

Polypeptoids, versatile peptidomimetic polymers, offer tunable properties for advanced applications. This review highlights synthetic methods and key characteristics driving their use in biomedical and biotechnological fields.

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Area of Science:

  • Macromolecular science
  • Supramolecular science and engineering
  • Polymer chemistry

Background:

  • Polypeptoids are peptidomimetic polymers with significant technological relevance.
  • Their chemical and structural diversity allows for fine-tuning of physicochemical and biological properties.
  • These properties include solubility, charge, conformation, HLB, thermal processability, degradability, cytotoxicity, and immunogenicity.

Purpose of the Study:

  • To review recent advancements in synthetic methodologies for creating well-defined polypeptoid structures.
  • To highlight fundamental physicochemical and biological properties of polypeptoids.
  • To underscore the potential of polypeptoids in developing functional materials for biomedical and biotechnological applications.

Main Methods:

  • Review of recent synthetic methods for polypeptoid synthesis.
  • Analysis of structure-property relationships in polypeptoids.
  • Compilation of data on physicochemical and biological characteristics.

Main Results:

  • Demonstration of diverse synthetic routes to access structurally defined polypeptoids.
  • Elucidation of how chemical and structural modifications influence key properties.
  • Identification of polypeptoids as promising candidates for various applications due to their tunable attributes.

Conclusions:

  • Polypeptoids represent a versatile synthetic polymer platform with significant potential.
  • Well-defined synthesis and understanding of properties are crucial for future material development.
  • Continued research into polypeptoids will drive innovation in biomedical and biotechnological fields.