Related Experiment Video
Updated: Feb 20, 2026
09:52
A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
18.1K
Chronic inflammation predicts long-term mortality in patients with Raynaud's phenomenon
M Mueller1, M E Gschwandtner1, J Gamper2
1Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
Journal of Internal Medicine
|October 26, 2017
Summary
Subclinical chronic inflammation markers, including low hemoglobin, predict mortality in incipient Raynaud's phenomenon. Hemoglobin concentration showed the strongest link to patient mortality risk.
Area of Science:
- Rheumatology
- Internal Medicine
- Vascular Medicine
Background:
- Subclinical chronic inflammation may link abnormal nailfold capillaries and autoantibodies to mortality in incipient Raynaud's phenomenon.
- The prognostic value of laboratory markers of chronic inflammation for mortality in Raynaud's phenomenon is unknown.
Purpose of the Study:
- To investigate the association between laboratory markers of chronic inflammation and long-term mortality in patients with incipient Raynaud's phenomenon.
Main Methods:
- 2958 patients with incipient Raynaud's phenomenon were enrolled.
- Laboratory tests (CRP, leucocytes, fibrinogen, haemoglobin), nailfold capillaries, and antinuclear antibodies (ANA) were assessed at baseline.
- Mortality was recorded over a median follow-up of 9.3 years.
Main Results:
- Baseline CRP, fibrinogen, and haemoglobin were associated with mortality individually.
- In multivariable analysis, low haemoglobin concentration remained independently related to future mortality.
- Low haemoglobin concentration was the strongest predictor of mortality in this cohort.
Conclusions:
- Laboratory markers of chronic inflammation provide prognostic information in Raynaud's phenomenon, independent of nailfold capillaries and ANA.
- Hemoglobin concentration is the most significant mortality predictor among all assessed markers in Raynaud's phenomenon.
Related Concept Videos
01:38Inflammation
62.6K
Overview
62.6K
01:27Psychoneuroimmunology: Cardiovascular Disease
594
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
594
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.9K
01:30Coronary Artery Disease I: Introduction
1.2K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.2K
01:23Rheumatic Heart Disease I: Introduction
589
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
589
01:21Myocarditis I: Introduction
460
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
460