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Updated: Feb 20, 2026

Measuring Proliferation of Vascular Smooth Muscle Cells Using Click Chemistry
Published on: October 30, 2019
Click Chemistry: Novel Applications in Cell Biology and Drug Discovery
Matthias Gehringer1, Stefan A Laufer1
1Eberhard Karls Universität Tübingen, Institute of Pharmaceutical Sciences, Pharmaceutical and Medicinal Chemistry, Auf der Morgenstelle 8, 72076, Tübingen, Germany.
Abstract:
A safe BET: Apart from target engagement, subcellular location and tissue distribution are critical parameters in drug discovery. A novel, generalizable approach has been reported that involves exploiting click chemistry to elucidate these parameters. By using clickable analogues of known Bromodomain and extraterminal domain (BET) inhibitors, various labels were introduced in situ and utilized to determine the biological fate of these probes.

