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MICRODOSIMETRIC APPLICATIONS IN PROTON AND HEAVY ION THERAPY USING SILICON MICRODOSIMETERS
L Chartier1, L T Tran1, D Bolst1
1Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia.
Radiation Protection Dosimetry
|October 26, 2017
Summary
Microdosimetric measurements using a novel probe reveal dose-equivalent values in proton and carbon-ion therapy. These findings are crucial for calculating healthy tissue doses and managing organ motion in hadron therapy.
Area of Science:
- Medical Physics
- Radiation Oncology
- Nuclear Physics
Background:
- Accurate dose assessment is critical in hadron therapy to minimize radiation exposure to healthy tissues.
- Microdosimetry provides detailed information about energy deposition crucial for understanding biological effects.
Purpose of the Study:
- To perform microdosimetric measurements in proton and carbon-ion therapy fields.
- To assess dose-equivalent values out-of-field and in-field.
- To investigate the impact of organ motion on treatment outcomes using microdosimetric spectra.
Main Methods:
- Utilized the CMRP 'bridge' μ+ probe for microdosimetric measurements.
- Conducted measurements with a scanning proton pencil beam (out-of-field) and a 12C ion therapy field (in-field).
- Performed measurements at Mayo Clinic, USA, and HIMAC, Japan.
Main Results:
- Observed dose-equivalent values of 0.62–0.99 mSv/Gy downstream of the distal edge in proton fields.
- Measured lateral dose-equivalent values reaching up to 5.3 mSv/Gy near the field edge, decreasing to ~0.04 mSv/Gy at 120 mm.
- Demonstrated significant differences in microdosimetric spectra and RBE10 due to simulated organ motion, particularly with 12C ions.
Conclusions:
- High spatial resolution microdosimetry is essential for accurate healthy tissue dose calculations in hadron therapy.
- Organ motion can significantly alter dose distributions and biological effectiveness, highlighting the importance of motion management strategies.
- Microdosimetric measurements provide valuable insights into treatment uncertainties and biological risks in particle therapy.
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