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Published on: October 19, 2014
[Effect of B Cell Differentiation Markers on the Prognosis of Primary Central Nervous System Lymphoma]
Xiang-Lei Chen1, Xiao-Yun Li2, Wei Wang3
1Department of Radio Therapy, Yidu Central Hospital of Weifang, Weifang 262500, Shangdong Province, China.
Objective:
To investigate the value of B-cell differentiation markers in prognosis evaluation of 119 patients with primary CNS lymphoma(PCNSL).
Methods:
The expressions of BCL-2, BCL-6, CD10 and MUM1/IRF4 protein were determined by immunohistochemistry, and their relationship with the prognosis of primary central nervous system lymphoma was analyzed.
Results:
Univariate analysis showed that BCL-6 positive means shorter PFS (P=0.047) and OS (P=0.035). Multivariate analysis showed that BCL-6 positive expression was related with shorter PFS (hazard ratio:1.95, 95% CI: 1.22- 3.12, P=0.005), but did not relate with OS (hazard ratio: 1.85, 95% CI: 0.71- 4.80, P=0.21). Classification based on Hans algorithm and expression status of the single B-cell markers BCL-2, CD10 and MUM1/IRF4 did not correlate with prognosis.
Conclusion:
BCL-6 may be an unfavorable prognostic biomarker for PCNSL.
