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Updated: Feb 20, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Targeted Nanomaterials for Phototherapy
Upendra Chitgupi1, Yiru Qin1, Jonathan F Lovell1
1Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, USA.
Abstract:
Phototherapies involve the irradiation of target tissues with light. To further enhance selectivity and potency, numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed. Active targeting typically involves harnessing the affinity between a ligand and a cell surface receptor for improved accumulation in the targeted tissue. Targeting ligands including peptides, proteins, aptamers and small molecules have been explored for phototherapy. In this review, recent examples of targeted nanomaterials used in phototherapy are summarized.
Insights
Molecularly targeted photosensitizers and nanoparticles enhance phototherapy selectivity. This review summarizes recent targeted nanomaterials for improved light-based treatment efficacy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Photomedicine
Background:
- Phototherapies utilize light irradiation for treating target tissues.
- Developing molecularly targeted photosensitizers and nanoparticles improves treatment selectivity and potency.
- Active targeting leverages ligand-receptor interactions for enhanced accumulation in target tissues.
Purpose of the Study:
- To review recent advancements in targeted nanomaterials for phototherapy.
- To highlight the application of various targeting ligands in enhancing phototherapy efficacy.
Main Methods:
- Literature review of targeted nanomaterials in phototherapy.
- Analysis of different targeting ligands (peptides, proteins, aptamers, small molecules).
- Summarization of recent examples of nanomaterial-based targeted phototherapy.
Main Results:
- Numerous molecularly targeted photosensitizers and photoactive nanoparticles have been developed.
- Targeting ligands facilitate improved accumulation of therapeutic agents in target tissues.
- Recent studies showcase diverse targeted nanomaterials for enhanced phototherapy.
Conclusions:
- Targeted nanomaterials represent a promising strategy to improve the selectivity and efficacy of phototherapies.
- The development of novel targeting ligands and nanomaterial designs continues to advance the field of photomedicine.
