Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Solitary Rectal Ulcer Syndrome Revisited: A Comprehensive Narrative Review.

Current gastroenterology reports·2026

Same author

Adoption and validation of the European Association for the Study of the Liver algorithm for the noninvasive diagnosis of advanced fibrosis in metabolic dysfunction-associated steatotic liver disease in low-resource South Asian settings.

PloS one·2026

Same author

Waitlist mortality in the early stages of a deceased-donor liver transplant program in Sri Lanka.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2025

Same author

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review.

Journal of general and family medicine·2025

Same author

The Exodus and Its Toll: Sri Lanka's Economic Crisis and the Migration of Doctors.

The International journal of health planning and management·2025

Same author

Abdominal Migraine in Adults: A Narrative Review.

Cureus·2025

Same journal

Jejunal Leiomyosarcoma in a Young Adult: Distinguishing from Gastrointestinal Stromal Tumor through Radiographic, Histologic, and Epidemiologic Analysis - A Case Report.

Gastrointestinal tumors·2024

Same journal

The Incidence and Outcomes of Venous Thromboembolisms in Patients Admitted with Different Gastrointestinal Malignancies.

Gastrointestinal tumors·2024

Same journal

Current Surgical Methods in Local Rectal Excision.

Gastrointestinal tumors·2024

Same journal

A Retrospective Study of Clinical Outcomes for Patients with Esophageal Cancer Who Were Treated with Radiotherapy Alone.

Gastrointestinal tumors·2024

Same journal

Investigation of Novel Urinary Biomarkers in Hepatocellular Carcinoma Risk in a Predominantly African American Population: A Case-Control Study.

Gastrointestinal tumors·2024

Same journal

Real-World Outcomes of FLOT versus CROSS Regimens for Patients with Oesophagogastric Cancers.

Gastrointestinal tumors·2023

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 20, 2026

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

Diffuse-Type Hepatoma: A Grave Prognostic Marker.

Rohan C Siriwardana¹, Chandika A H Liyanage¹, Bhagya Gunetilleke¹

¹Department of Surgery, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

Gastrointestinal Tumors

|October 27, 2017

Summary

This summary is machine-generated.

Diffuse-type hepatocellular carcinoma (HCC) is linked to higher alpha fetoprotein (AFP) and vascular invasion, resulting in a poorer prognosis compared to nodular HCC. This study highlights the aggressive nature of diffuse HCC in a non-infectious hepatitis cohort.

Keywords:

Hepatocellular carcinoma, pathology, diagnosis Neoplasm staging Neoplasm, invasiveness Prognosis Survival rate

More Related Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Related Experiment Videos

Last Updated: Feb 20, 2026

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Mass Cytometry Analysis of Systemic and Local Immune Responses in Hepatocellular Carcinoma

Published on: April 25, 2025

Area of Science:

Hepatology
Oncology
Radiology

Background:

Hepatocellular carcinoma (HCC) incidence is rising in Sri Lanka, often linked to nonalcoholic fatty liver disease.
Data on diffuse-type HCC, a less common form, are scarce.
This study focuses on comparing nodular and diffuse HCC in a Sri Lankan cohort negative for infective hepatitis.

Purpose of the Study:

To compare the clinical characteristics, treatment, and outcomes of nodular versus diffuse-type HCC.
To investigate the prognostic factors associated with diffuse-type HCC in this specific population.

Main Methods:

CT scans of 227 HCC patients (non-infective hepatitis) were analyzed between July 2011 and July 2014.
Patients were classified into nodular or diffuse types based on tumor margins and infiltration patterns.
Clinical data, including liver function, etiology, treatment, and survival, were compared between the two groups. Stage III diffuse HCC cases were matched with Stage III nodular HCC cases.

Main Results:

Diffuse HCC (20% of cases) presented with lower BMI, higher alpha fetoprotein (AFP) levels, and increased major vascular invasion compared to nodular HCC.
A significant proportion of diffuse HCC patients were ineligible for active treatment.
Overall survival was markedly poorer for diffuse HCC (4.7 months) versus nodular HCC (25 months), including Stage III matched cases (2.5 vs. 15.8 months).

Conclusions:

Diffuse-type HCC, particularly in the absence of infective hepatitis, is associated with unfavorable prognostic indicators.
High AFP levels and major vascular invasion are key features of diffuse HCC.
Diffuse-type HCC demonstrates a significantly poorer prognosis compared to nodular-type HCC.