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Cell Based Therapeutic Approach in Vascular Surgery: Application and Review
Aldo Rocca1, Domenico Tafuri2, Marianna Paccone3
1Department of Translational Medical Sciences, University of Naples Federico II, Naples, ItalyVia Sergio Pansini, 80131Naples, Italy.
Open Medicine (Warsaw, Poland)
|October 27, 2017
Summary
Adult vascular wall stem cells show promise for cell-based therapies in vascular diseases. Their recruitment, differentiation, and survival are key factors for successful translation from research to clinical applications.
Area of Science:
- Regenerative Medicine
- Vascular Biology
- Stem Cell Biology
Background:
- Multipotent stem cells, including mesenchymal stem/stromal cells and vascular wall-derived stem cells, are under intense investigation for clinical translation.
- Understanding the biology of vascular wall resident stem cells is crucial for developing effective cell-based therapies.
Purpose of the Study:
- To analyze the recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways of vascular wall resident stem cells.
- To explore the relationship between stem cell properties and factors like Matrix Metalloproteinases (MMPs).
- To describe a translational and clinical approach for Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs).
Main Methods:
- Review of existing literature on vascular wall resident stem cells.
- Analysis of biological properties, including stem cell recruitment, differentiation, and survival.
- Exploration of regulatory factors such as MMPs and their impact on stem cell functions.
Main Results:
- Vascular wall resident stem cells possess multipotent characteristics relevant for therapeutic applications.
- Factors like MMPs influence the biological, translational, and clinical features of these stem cells.
- VW-SCs are implicated in alternative clinical approaches for vascular diseases.
Conclusions:
- Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) offer a promising avenue for cell-based therapies.
- Further research into VW-SC biology and regulation is essential for clinical translation in treating vascular diseases like aneurysms and peripheral arterial obstructive disease.
