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Related Experiment Videos

D-1 and D-2 receptor antagonists decrease corn oil sham feeding in rats.

S C Weatherford1, G P Smith, L D Melville

  • 1Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605.

Physiology & Behavior
|January 1, 1988
PubMed
Summary
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Dopamine D-1 and D-2 receptors are crucial for processing the taste and reward of food. Blocking these dopamine receptors significantly reduces corn oil intake in rats during sham feeding.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

Background:

  • Dopamine plays a significant role in reward processing and motivated behaviors, including feeding.
  • Specific dopamine receptor subtypes (D-1 and D-2) are implicated in various aspects of food intake regulation.

Purpose of the Study:

  • To investigate the necessity of central dopaminergic activity at D-1 and D-2 receptors for the regulation of food intake.
  • To determine the effects of selective D-1 and D-2 receptor antagonists on corn oil consumption in a sham-feeding paradigm.

Main Methods:

  • Rats were administered intraperitoneal injections of selective D-1 receptor antagonist SCH 23390 and D-2 receptor antagonist (-)-raclopride.
  • Food intake was measured during a 30-minute sham-feeding test following antagonist administration.

Related Experiment Videos

  • Dose-response relationships were established, and motor activity was assessed.

    • Main Results:

    • Both SCH 23390 and (-)-raclopride produced a dose-related decrease in corn oil intake.
    • Significant reductions in intake were observed at threshold doses of 100 µg/kg for SCH 23390 and 200 µg/kg for (-)-raclopride.
    • The tested doses did not affect the latency to initiate sham feeding or cause motor deficits.

    Conclusions:

    • Central dopaminergic activity at both D-1 and D-2 receptors is essential for normal sensory and hedonic processing of food stimuli during sham feeding.
    • These findings support the hypothesis that dopamine signaling through both receptor types is critical for regulating food intake based on palatability and reward.