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Temporal Bias: Time-Encoded Dynamic GPCR Signaling.

Manuel Grundmann¹, Evi Kostenis²

¹Molecular-, Cellular- and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, Germany; Kidney Disease Research, Bayer Pharma AG, Aprather Weg 18a, 42113 Wuppertal, Germany.

Trends in Pharmacological Sciences

|October 28, 2017

Summary

Cells use time-encoded signals for information processing. This review explores how G-protein-coupled receptors (GPCRs) generate

Keywords:

G-protein-coupled receptors signaling dynamics signaling networks spatiotemporal signaling temporal bias

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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

Area of Science:

Cellular signaling and biophysics.
Molecular and systems biology.
Signal transduction mechanisms.

Background:

Cellular communication relies on signal encoding for information transfer.
G-protein-coupled receptors (GPCRs) are crucial cell surface receptors involved in diverse physiological processes.
The temporal dynamics of GPCR signaling are increasingly recognized as critical for biological information processing.

Purpose of the Study:

To review the mechanisms by which GPCRs encode biological information in time, creating 'temporal bias'.
To highlight dynamic signaling patterns across different molecular levels within GPCR networks.
To explore the implications of temporal bias in GPCR signaling for cell physiology.

Main Methods:

Review of existing literature on GPCR signaling dynamics.
Analysis of temporal aspects of second messenger signaling.
Examination of G-protein cycle kinetics and ligand-receptor interaction dynamics.
Investigation of cellular signaling wave propagation.

Main Results:

GPCR signaling networks exhibit temporal flexibility in their composition and signal transduction.
Dynamic signaling patterns, including temporal bias, are observed from second messengers to receptor-ligand interactions.
Distinct signaling waves and G-protein cycle kinetics contribute to time-encoded information in GPCR pathways.

Conclusions:

Temporal bias is a key feature of GPCR signaling, adding complexity to signal interpretation.
Understanding the time-encoded nature of GPCRs may offer new avenues for controlling cell physiology.
Exploiting temporal bias in GPCRs could lead to novel therapeutic strategies for diseases involving cell signaling dysregulation.