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Updated: Feb 20, 2026
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
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Photodynamic therapy as initial treatment for small choroidal melanomas.
F Jmor1, R N Hussain1, B E Damato2
1Liverpool Ocular Oncology Clinic, St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
Photodiagnosis and Photodynamic Therapy
|October 28, 2017
Summary
Verteporfin photodynamic therapy (PDT) can achieve tumor regression in some small choroidal melanomas. However, PDT is less reliable than other treatments and may require further radiotherapy.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Choroidal melanoma is a rare eye cancer.
- Early detection and treatment are crucial for preserving vision.
Purpose of the Study:
- To evaluate Verteporfin photodynamic therapy (PDT) as a primary treatment for small, posterior choroidal melanomas.
Main Methods:
- Retrospective cohort review of 20 patients with small choroidal melanomas treated with PDT.
- Analysis of patient and tumor characteristics, PDT details, visual acuity, and imaging data.
Main Results:
- Tumor regression observed in 80% of patients (11 complete, 5 partial).
- Two cases (10%) required alternative treatment due to tumor growth.
- Mean visual acuity decreased post-PDT, with a mean follow-up of 60 months.
Conclusions:
- PDT can induce tumor regression in a significant proportion of small choroidal melanomas.
- PDT is less reliable than other therapies and may necessitate further treatment.
- PDT might be considered for patients with specific visual needs, accepting a higher risk of treatment failure.
