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Equilibrium binding of spermine and histamine to salmon sperm DNA and poly(dGdC)
1Department of Chemistry, Rutgers University, Piscataway, NJ 08855.
The Journal of Pharmacy and Pharmacology
|November 1, 1988
Abstract:
Studies using the solute-enhanced phase partition technique demonstrate that the endogenous amines histamine and spermine bind to both salmon sperm DNA and poly(dGdC) in a markedly cooperative fashion. Both compounds exhibited DNA sequence-dependence effects in their mode of binding. The linear aliphatic spermine molecule binds more strongly than histamine to both DNA types.