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Insulin-like growth factor II messenger RNA-binding protein-3 is an independent prognostic factor in uterine
Nobuko Yasutake1, Yoshihiro Ohishi1, Kenichi Taguchi2
1Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Aims:
The aim of this study was to identify the prognostic factors of uterine leiomyosarcoma (ULMS).
Methods And Results:
We reviewed 60 cases of surgically resected ULMSs and investigated conventional clinicopathological factors, together with the expression of insulin-like growth factor II messenger RNA-binding protein-3 (IMP3), hormone receptors and cell cycle regulatory markers by immunohistochemistry. Mediator complex subunit 12 (MED12) mutation analysis was also performed. Univariate analyses revealed that advanced stage (P < 0.0001), older age (P = 0.0244) and IMP3 expression (P = 0.0011) were significant predictors of a poor outcome. Multivariate analysis revealed advanced stage (P < 0.0001) and IMP3 (P = 0.0373) as independent predictors of a poor prognosis. Expressions of cell cycle markers and hormone receptors, and MED12 mutations (12% in ULMSs) were not identified as prognostic markers in this study.
Conclusions:
IMP3 expression in ULMS could be a marker of a poor prognosis.
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