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[INFECTIONS IN PATIENTS WITH CIRRHOSIS AND LIVER TRANSPLANTATION].

T Filipec Kanižaj, I Košuta, G Cavrić

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    Patients with liver cirrhosis or undergoing liver transplantation face a higher risk of bacterial infections due to altered immune responses. Early diagnosis and treatment are crucial for better outcomes in these vulnerable populations.

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    Area of Science:

    • Immunology
    • Hepatology
    • Transplantation Medicine

    Background:

    • Altered immune responses are characteristic of liver cirrhosis and liver transplantation.
    • Patients with advanced liver disease and transplant recipients have an increased susceptibility to bacterial infections.
    • These infections often present with atypical clinical signs, and classic inflammatory responses may be blunted or absent.

    Purpose of the Study:

    • To highlight the increased risk and atypical presentation of bacterial infections in patients with liver cirrhosis and liver transplant recipients.
    • To emphasize the critical role of timely diagnosis and intervention for favorable outcomes.
    • To underscore the significance of bacterial infections as a major cause of morbidity and mortality in these patient groups.

    Main Methods:

    • This abstract is based on a review of existing literature and clinical observations regarding immune function in liver disease and transplantation.
    • The content synthesizes information on infection risks, clinical presentations, and outcomes.
    • No specific experimental methods were detailed in the provided abstract.

    Main Results:

    • Bacterial infections are a leading cause of morbidity and mortality in advanced liver disease, with a doubled risk of fatal sepsis.
    • Post-liver transplantation, bacterial infections are significant complications, despite improvements in surgical techniques and immunosuppression.
    • Atypical presentations are common, complicating diagnosis.

    Conclusions:

    • Patients with liver cirrhosis and liver transplant recipients are at high risk for bacterial infections with unusual clinical manifestations.
    • Prompt diagnosis and effective therapeutic strategies are essential for improving patient survival and outcomes.
    • Managing these infections is critical for reducing morbidity and mortality in these immunocompromised populations.