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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Bone mineral density in familial partial lipodystrophy.

Antía Fernández-Pombo1,2, Javier A Ossandon-Otero1, Cristina Guillín-Amarelle1,2

  • 1UETeM-Molecular Pathology Group, Department of Medicine, IDIS-CIMUS, University of Santiago de Compostela, Santiago de Compostela, Spain.

Clinical Endocrinology
|October 28, 2017
PubMed
Summary

Familial partial lipodystrophies (FPLD) do not affect bone mineral density (BMD). This study found no significant differences in BMD between FPLD patients and controls, suggesting bone health is preserved in FPLD.

Keywords:
LMNAbody compositionbone densitydual-energy X-ray absorptiometryfamilial partial lipodystrophylaminopathies

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Genetics

Background:

  • Familial partial lipodystrophies (FPLD) types 1 and 2 involve fat distribution abnormalities and metabolic issues.
  • Increased muscle mass is sometimes observed in FPLD patients.
  • Potential bone involvement in FPLD has not been previously investigated.

Purpose of the Study:

  • To assess bone mineral density (BMD) in individuals diagnosed with FPLD type 1 and type 2.
  • To determine if FPLD impacts skeletal integrity compared to healthy controls.

Main Methods:

  • 143 women were categorized into FPLD1 (n=82), FPLD2 (n=17), and non-lipodystrophic obese controls (n=44).
  • Bone mineral density (BMD), fat mass, and fat-free mass (FFM) were measured using dual-energy X-ray absorptiometry (DXA).
  • Statistical analyses, including ANCOVA, controlled for age, height, fat mass, and FFM.

Main Results:

  • No statistically significant differences in total or segmental BMD were observed between FPLD patients (FPLD1 and FPLD2) and the control group.
  • Adjusted total BMD values were 1.092 ± 0.037 g/cm² for FPLD2, 1.158 ± 0.013 g/cm² for FPLD1, and 1.173 ± 0.018 g/cm² for controls (P = 0.194).

Conclusions:

  • FPLD does not appear to be associated with altered bone mineral density.
  • Unlike other laminopathies affecting bone, FPLD patients exhibit comparable BMD to non-lipodystrophic individuals.