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Comparing the Host Reaction to CorMatrix and Different Cardiac Patch Materials Implanted Subcutaneously in Growing
Zahra Mosala Nezhad1,2, Alain Poncelet1,2, Caroline Fervaille3
1Department of Cardiovascular and Thoracic Surgery, Cliniques Universitaire Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
The Thoracic and Cardiovascular Surgeon
|October 28, 2017
Summary
CorMatrix patches showed complete resorption and tissue remodeling in pigs, unlike xenopericardial patches which caused fibrosis. This suggests CorMatrix facilitates better tissue integration and healing.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Evaluating host responses to implanted biomaterials is crucial for developing effective medical devices.
- Understanding the degradation and integration of synthetic scaffolds versus natural pericardium is key.
Purpose of the Study:
- To compare the structural changes and host reactions to CorMatrix and other biomaterials.
- To assess the long-term tissue integration and remodeling of implanted patches in a preclinical model.
Main Methods:
- Subcutaneous implantation of CorMatrix, Vascutek porcine pericardium, SJM bovine pericardium, and Gore-Tex patches in a growing pig model.
- Histological examination of explants at 1, 3, 6, and 12 months post-implantation.
Main Results:
- CorMatrix demonstrated gradual resorption, with complete scaffold degradation and replacement by mild fibrosis and subcutaneous tissue within 1 year.
- Xenopericardial patches remained intact, showing reduced but persistent severe inflammatory and fibrotic reactions.
- Gore-Tex elicited a foreign body reaction, while CorMatrix allowed tissue ingrowth and remodeling without significant fibrosis.
Conclusions:
- CorMatrix is completely resorbed and degraded without residues, promoting tissue ingrowth and matrix remodeling.
- Xenopericardial patches result in encapsulating fibrosis and lack remodeling.
- The pig model demonstrated biotolerance to all tested patches, with CorMatrix showing superior integration characteristics.
