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Related Experiment Video

Updated: Feb 20, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
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Sepsis in Older Adults.

Theresa A Rowe1, June M McKoy1

  • 1General Internal Medicine and Geriatrics, Northwestern University Feinberg School of Medicine, 750 North Lakeshore Drive, 10th Floor, Chicago, IL 60611, USA.

Infectious Disease Clinics of North America
|October 29, 2017
PubMed
Summary

Sepsis primarily impacts older adults, posing unique clinical challenges. Management requires tailored approaches considering comorbidities, cognitive status, and functional decline for better outcomes.

Keywords:
InfectionsOlder adultsOutcomesSepsis

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Area of Science:

  • Geriatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Sepsis disproportionately affects adults aged 65 and older, accounting for over 60% of diagnoses.
  • Diagnosing and treating sepsis in elderly patients presents significant clinical challenges, particularly those with multiple comorbidities.
  • Existing research often overlooks the specific needs of older adults with complex medical histories.

Purpose of the Study:

  • To highlight the unique considerations for managing sepsis in older adults.
  • To emphasize the importance of factors beyond chronological age in sepsis care for the elderly.
  • To provide guidance on specific aspects of sepsis management in geriatric populations.

Main Methods:

  • Review of current literature on sepsis management in older adults.
  • Analysis of factors influencing sepsis outcomes in the geriatric population.
  • Discussion of age-specific challenges in diagnosis and treatment.

Main Results:

  • While core sepsis management principles apply, older adults require special attention to antimicrobial selection, dosing, delirium management, and goals of care.
  • Medical comorbidities, cognitive impairment, and functional status are more critical determinants of outcomes than age alone.
  • Tailored clinical strategies are essential for effective sepsis care in the elderly.

Conclusions:

  • Sepsis management in older adults necessitates a personalized approach, integrating clinical status with age-related factors.
  • Clinicians must address unique challenges such as polypharmacy, frailty, and cognitive decline when treating sepsis in the elderly.
  • Further research focusing on evidence-based guidelines for geriatric sepsis is warranted to improve patient outcomes.