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Updated: Feb 20, 2026
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Endometriosis, especially mild disease: a risk factor for miscarriages
Alexandra Sabrina Kohl Schwartz1, Monika Martina Wölfler2, Vera Mitter3
1Department of Reproductive Endocrinology, University Hospital Zurich, Zurich, Switzerland; Division of Gynecological Endocrinology and Reproductive Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
Objective:
To investigate the prevalence of miscarriage in women with endometriosis (WwE) compared with disease-free control women (CW).
Design:
Cross-sectional analysis nested in a retrospective observational study (n = 940).
Setting:
Hospitals and associated private practices.
Patient(S):
Previously pregnant women (n = 268) within reproductive age in matched pairs.
Intervention(S):
Retrospective analysis of surgical reports and self-administered questionnaires.
Main Outcome Measure(S):
Rate of miscarriage, subanalysis for fertility status (≤12 vs. >12 months' time to conception), endometriosis stages (revised American Society of Reproductive Medicine classification [rASRM] I/II vs. III/IV) and phenotypic localizations (superficial peritoneal, ovarian, and deep infiltrating endometriosis).
Result(S):
The miscarriage rate was higher in WwE (35.8% [95% confidence interval 29.6%-42.0%]) compared with CW (22.0% [16.7%-27.0%]); adjusted incidence risk ratio of 1.97 (95% CI 1.41-2.75). This remained significant in subfertile WwE (50.0% [40.7%-59.4%]) vs. CW (25.8% [8.5%-41.2%]) but not in fertile WwE (24.5% [16.3%-31.6%]) vs. CW (21.5% [15.9%-26.8%]). The miscarriage rate was higher in women with milder forms (rASRM I/II 42.1% [32.6%-51.4%] vs. rASRM III/IV 30.8% [22.6%-38.7%], compared with 22.0% [16.7%-27.0%] in CW), and in women with superficial peritoneal endometriosis (42.0% [32.0%-53.9%]) compared with ovarian endometriosis (28.6% [17.7%-38.7%]) and deep infiltrating endometriosis (33.9% [21.2%-46.0%]) compared with CW (22.0% [16.7%-27.0%]).
Conclusion(S):
Mild endometriosis, as in superficial lesions, is related to a great extent of inflammatory disorder, possibly leading to defective folliculogenesis, fertilization, and/or implantation, presenting as increased risk of miscarriage.
Clinical Trial Registration Number:
NCT02511626.
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