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[Pharmacogenetic studies on drug dependence].

T Suzuki1

  • 1Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.

Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
|September 1, 1988
PubMed
Summary

Genetic factors significantly influence drug dependence. Research using inbred animal strains and selective breeding demonstrates that genetics control drug effects, tolerance, and dependence, aiding in understanding substance abuse.

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Area of Science:

  • Pharmacogenetics
  • Neuroscience
  • Genetics

Context:

  • Recent advancements have significantly improved understanding of genetic influences on drug dependence.
  • Pharmacogenetic studies are crucial for dissecting the biological underpinnings of substance abuse.
  • Genetically uniform inbred animal strains provide a robust model for studying genetic determination of drug responses.

Purpose:

  • To review pharmacogenetic studies investigating the genetic factors contributing to drug dependence.
  • To highlight the utility of inbred animal strains and selective breeding in understanding drug abuse.
  • To explore the relationship between genetic makeup and the effects of abusable drugs.

Summary:

  • Evidence from inbred animal strains and selective breeding indicates that genetic factors control the acute effects, tolerance, and dependence associated with abusable drugs.
  • Comparing drug effects with various biochemical traits in genetically defined models offers insights into drug mechanisms.
  • Genetically defined animal models are essential tools for studying drugs of abuse, with model selection dependent on research objectives.

Impact:

  • Establishes a strong genetic basis for drug dependence and responses to drugs of abuse.
  • Provides a foundation for developing targeted pharmacotherapies and personalized medicine approaches for addiction.
  • Underscores the importance of considering genetic variability in drug dependence research and treatment strategies.

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