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A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
Published on: January 12, 2019
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Blood flow changes using a 3D xenogeneic collagen matrix or a subepithelial connective tissue graft for root coverage
Nikolaos Tatarakis1, Nikolaos Gkranias1, Ulpee Darbar2
1Centre for Oral Clinical Research, Institute of Dentistry, Barts & The London School of Medicine & Dentistry, Queen Mary University of London (QMUL), Turner Street, London, E1 2AD, UK.
Clinical Oral Investigations
|October 29, 2017
Summary
This study compared a 3D xenogeneic collagen matrix (CMX) with connective tissue graft (CTG) for treating gum recession. Both methods showed similar early healing, but CTG offered better root coverage while CMX resulted in less initial pain.
Area of Science:
- Periodontology
- Regenerative Dentistry
- Biomaterials Science
Background:
- Investigating early healing of gingival recession treatments.
- Comparing 3D xenogeneic collagen matrix (CMX) and connective tissue graft (CTG).
- Focus on Miller class I and II single recessions.
Purpose of the Study:
- To evaluate and compare the early healing processes of CMX and CTG in treating gingival recession.
- To assess vascular flow changes, clinical outcomes, and patient-reported pain.
- To determine the efficacy and patient morbidity associated with each graft type.
Main Methods:
- Pilot, single-center, randomized controlled parallel trial.
- Eight subjects treated with either CMX or CTG in the anterior maxilla.
- Laser Doppler flowmetry for vascular assessment; clinical evaluation for root coverage and tissue gain; SF-MPQ for pain.
Main Results:
- Similar pre- and post-operative vascular flow patterns observed in both groups.
- CTG showed a more homogeneous vascular pattern; CMX exhibited a secondary increase in blood flow at 14 days.
- CTG resulted in greater root coverage and keratinized tissue gain; CMX was associated with lower early pain scores.
Conclusions:
- Early healing vascularization patterns were similar for CMX and CTG.
- CTG demonstrated a trend towards superior clinical outcomes (root coverage, keratinized tissue).
- CMX offered the advantage of reduced initial patient morbidity compared to CTG.
