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Updated: Aug 12, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Checkpoint inhibitor-induced uveitis: a case series
Christopher D Conrady1, Marissa Larochelle1, Paula Pecen2
1Department of Ophthalmology, John A. Moran Eye Center, University of Utah, Salt Lake City, UT, 84112, USA.
Purpose:
Checkpoint inhibitors are now a common treatment modality for metastatic cancer. In this manuscript, we describe the clinical features and management of autoimmune non-infectious uveitis induced by this class of drugs.
Methods:
Seven patients undergoing checkpoint inhibitor treatment for metastatic cancer from uveitis practices at three tertiary referral centers.
Results:
All seven patients developed various severities of ocular inflammatory disease while taking checkpoint inhibitors for metastatic disease.
Conclusions:
Checkpoint inhibitors may induce autoimmune uveitis. Ocular complaints should prompt an early evaluation by an ophthalmologist.
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