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Physical Properties of Amines01:26

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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
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Polyamines and Cancer.

Elisabetta Damiani1,2, Heather M Wallace3

  • 1School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Methods in Molecular Biology (Clifton, N.J.)
|October 29, 2017
PubMed
Summary
This summary is machine-generated.

The polyamine pathway is a key target in cancer treatment and prevention. Exploiting this pathway offers new strategies for chemotherapy, drug delivery, and chemoprevention in various cancers.

Keywords:
CancerChemopreventionChemotherapyDrug deliveryPolyamines

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Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • The polyamine pathway is significantly disrupted in all cancer types.
  • Polyamines play crucial roles in cell proliferation and are upregulated in cancerous cells.
  • Targeting the polyamine pathway presents a promising strategy for cancer intervention.

Purpose of the Study:

  • To provide a comprehensive overview of targeting the polyamine pathway for cancer treatment and prevention.
  • To explore polyamine pathway's role in chemotherapy, drug delivery, and chemoprevention.
  • To discuss the potential and challenges of various therapeutic strategies involving polyamines.

Main Methods:

  • Review of chemotherapy agents targeting the polyamine pathway, including difluoromethylornithine (DFMO) and polyamine analogues.
  • Investigation of polyamines as drug delivery vectors, utilizing their natural DNA binding and upregulated transport systems in cancer.
  • Analysis of chemoprevention strategies focused on interfering with polyamine metabolism and function.

Main Results:

  • Difluoromethylornithine (DFMO) and various polyamine analogues have been developed and tested for chemotherapy.
  • Polyamines and their analogues show potential as vectors for targeted delivery of therapeutic agents to cancer cells.
  • Strategies interfering with polyamine metabolism demonstrate antiproliferative effects, supporting chemoprevention.

Conclusions:

  • The polyamine pathway is a versatile target for developing novel cancer therapies.
  • Polyamines offer opportunities for both direct anti-cancer treatment and enhanced drug delivery systems.
  • Targeting polyamine metabolism is a viable approach for cancer chemoprevention and treatment.