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The aging rat retina: from function to anatomy.

Francisco M Nadal-Nicolás¹, Manuel Vidal-Sanz¹, Marta Agudo-Barriuso¹

¹Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca (IMIB-Arrixaca) and Departamento de Oftalmología Facultad de Medicina, Universidad de Murcia, Murcia, Spain.

Neurobiology of Aging

|October 29, 2017

Summary

This summary is machine-generated.

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Aging impairs vision by affecting retinal function and structure in rats. This study reveals age-related declines in both cone and rod responses, impacting visual health.

Area of Science:

Ophthalmology
Neuroscience
Gerontology

Background:

Aging is a primary cause of cellular dysfunction and death.
Age-related changes in the rat retina impact neuronal populations and visual function.
Controversial findings exist regarding age-related changes in the innermost retina.

Purpose of the Study:

To investigate age-related changes in both albino and pigmented rat retinas throughout their lifespan.
To compare functional and anatomical differences between albino and pigmented rat retinas concerning aging.

Main Methods:

Electroretinographic recordings to assess retinal function.
Measurement of retinal volume and layer dimensions.
Anatomical analysis of cell density and photoreceptor populations.

Keywords:

Anterograde axonal transport Brn3a Cone Melanopsin Microglia Optical coherence tomography Photoreceptors Rods

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Histological examination for gliosis and neural innervation.

Main Results:

Albino rats consistently showed smaller retinal volumes and layer dimensions compared to pigmented rats, irrespective of age.
Aging led to a decline in both cone- and rod-mediated electroretinographic responses in both rat strains.
While overall cell density decreased with age due to retinal growth, the ganglion cell layer remained unaffected. Pigmented rats showed a reduction in cone photoreceptors with age.
Old rats of both strains exhibited gliosis in the superior colliculi and reduced retinal ganglion cell innervation.

Conclusions:

Aging significantly impacts retinal function and structure in rats, affecting both cone and rod pathways.
Differences exist between albino and pigmented rat retinas in response to aging.
This research provides a foundation for understanding the link between senescence and neurodegenerative retinal diseases.