Related Experiment Video
Updated: Feb 19, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Application of induced pluripotent stem cells to model smooth muscle cell function in vascular diseases
HaYeun Ji1, Hye Sung Kim1, Hae-Won Kim2,3
1Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.
Abstract:
Vascular smooth muscle cells (SMC) play an essential role in remodeling the vasculature during disease progression. Induced pluripotent stem cells (iPSC) provide an attractive approach to obtain autologous SMC source for patient-specific disease modeling. Here we discuss the current methods to 1) derive functional SMC from iPSC, 2) model vascular diseases using SMC generated from patient-derived iPSC, and 3) modulate microenvironmental cues to enhance cellular differentiation and functionality and better mimic the physiological environment. We emphasize that continuous exploration of biomaterial technologies to engineer a more SMC-specific microenvironment will provide further insight on complex vascular diseases.
More Related Videos
08:28Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
Published on: February 15, 2022
04:41Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
Published on: December 13, 2024
Related Concept Videos
EPS and iPS Cells in Disease Research
Induced Pluripotent Stem Cells
iPS Cell Differentiation