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[Compatible principles of Xiebai decoction family based on complex network analysis]
Peng-Li Wang1,2, Yu-Hao Fan1,2, Xin-Sheng Fan1,2
1College of Basic Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Summary
This study analyzed Xiebai decoction family formulas using data mining. Mori Cortex, Lycii Cortex, and Glycyrrhizae Radix et Rhizoma form a core compatible group, aiding lung heat clearance and cough relief.
Area of Science:
- Traditional Chinese Medicine
- Herbal Medicine
- Pharmacology
Background:
- The Xiebai decoction family is a traditional herbal formula used for respiratory ailments.
- Understanding the compatibility principles of these herbs is crucial for optimizing their therapeutic efficacy.
Purpose of the Study:
- To explore the underlying compatible principles of the Xiebai decoction family.
- To identify core herbs and their relationships within this formula family.
Main Methods:
- Collection and sorting of ancient and modern Xiebai decoction family formulas.
- Application of data-mining techniques including scale-free network analysis, association rules, clustering analysis, and correspondence analysis.
Main Results:
- Scale-free network analysis identified Mori Cortex-Lycii Cortex-Glycyrrhizae Radix et Rhizoma as a core compatible group.
- Association rules revealed Mori Cortex, Lycii Cortex, Glycyrrhizae Radix et Rhizoma, scutellaria root, Platycodon root, Anemarrhena, and almond as key herbs.
- Clustering analysis confirmed Mori Cortex as the central herb, often combined with Lycii Cortex and Glycyrrhizae Radix et Rhizoma, and supplemented with herbs for clearing heat, reducing phlegm, supplementing Qi, and nourishing Yin.
Conclusions:
- The core compatibility features of the Xiebai decoction family involve clearing lung heat and relieving cough and asthma.
- These findings provide a scientific basis for the clinical application of Xiebai decoction family prescriptions.
