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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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Kidney function is associated with short-term, mid-term and long-term clinical outcome after coronary angiography and

Andrie G Panayiotou1, Jonas Spaak2, Majid Kalani2

  • 1a Cyprus International Institute for Environmental and Public Health , Cyprus University of Technology , Limassol , Cyprus.

Acta Cardiologica
|October 31, 2017
PubMed

Insights

Kidney dysfunction increases heart disease risk. Lower estimated glomerular filtration rate (eGFR) is linked to higher mortality and re-hospitalization after coronary procedures, highlighting the need for integrated care.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Outcomes

Background:

  • Patients with impaired kidney function face elevated risks of ischemic heart disease.
  • The relationship between estimated glomerular filtration rate (eGFR) and clinical outcomes in patients undergoing cardiac procedures requires further investigation.

Purpose of the Study:

  • To examine the association between eGFR and early, mid, and long-term clinical outcomes in patients who underwent coronary angiography and intervention.

Main Methods:

  • A retrospective study included 4968 patients with complete eGFR data, who underwent coronary angiography and intervention between 2006-2008.
  • Patient data were analyzed with follow-up periods censored at 30 days, 365 days, and 1825 days.

Main Results:

  • A significant association was found between baseline eGFR and all-cause mortality across all follow-up periods.
  • Each 10 mL/min/1.73 m² increase in eGFR correlated with a substantial decrease in mortality and re-hospitalization for myocardial infarction (MI).
  • eGFR was also linked to re-vascularization risk at 30 days and new MI at mid-term follow-up.

Conclusions:

  • Kidney function, indicated by eGFR, strongly correlates with all-cause mortality and adverse cardiovascular events in patients undergoing coronary procedures.
  • eGFR is associated with MI-related mortality, re-vascularization risk, and new MI, underscoring the link between kidney function and cardiovascular disease.
  • Further research into the mechanisms connecting kidney function and cardiovascular disease is crucial for improving patient care.
Abstract

Keywords:
eGFRmortalitymyocardial infarctionrevascularisation

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