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Updated: Feb 19, 2026

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
Published on: January 20, 2023
Risk Factors for Prolonged Symptoms of Mild Traumatic Brain Injury: A Pediatric Sports Concussion Clinic Cohort
Shayne D Fehr1,2, Lindsay D Nelson, Kyle R Scharer2
1Department of Orthopaedic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Objective:
To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.
Design:
Retrospective chart review.
Setting:
Outpatient specialty clinic.
Patients:
Charts of 549 patients (age range: 10-18 years) with concussions were reviewed in an outpatient clinic that predominantly managed sports-related injuries (77.3%). Patients (n = 431) included in the final analysis met the criteria for mTBI and were symptomatic at their first visit.
Assessment Of Risk Factors:
Patient history, injury, and recovery variables were evaluated.
Main Outcome Measures:
Predictors of prolonged time to reach self-reported symptom recovery were evaluated using Cox proportional hazards.
Results:
Median time to symptom recovery of the 431 patients who presented to clinic with symptoms was 40 days (full clinic sample median = 34 days). Analyses identified 3 unique predictors of symptom recovery: loss of consciousness (LOC) [hazard ratio (HR) = 0.56, P < 0.0001], female sex (HR = 0.57, P < 0.0001), and concussion symptom score at first clinic visit (HR = 0.76, P < 0.0001).
Conclusions:
Prolonged duration of mTBI symptoms in patients who present to a pediatric sports-based concussion clinic is related to initial symptom severity, female sex, and LOC.
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