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Related Experiment Video

Updated: Feb 19, 2026

Frailty Assessment in an Aging Mouse Model
06:58

Frailty Assessment in an Aging Mouse Model

Published on: September 23, 2025

656

Frailty Phenotype and Neuropsychological Test Performance: A Preliminary Analysis.

Terrie B Ginsberg, Leonard Powell, Arif Patel

    The Journal of the American Osteopathic Association
    |October 31, 2017
    PubMed
    Summary
    This summary is machine-generated.

    Frailty in older adults is linked to poorer cognitive function. This study found that increased frailty correlates with deficits in executive control, working memory, and delayed recognition memory.

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    Area of Science:

    • Geriatric Medicine
    • Neuropsychology
    • Cognitive Aging

    Background:

    • Frailty is prevalent in adults over 65.
    • The link between frailty and cognitive impairment requires further investigation.

    Purpose of the Study:

    • To assess the association between frailty phenotype and cognitive screening.
    • To explore frailty's relationship with specific neuropsychological domains relevant to mild cognitive impairment and dementia.

    Main Methods:

    • Retrospective analysis of ambulatory patients aged 65+.
    • Utilized Montreal Cognitive Assessment (MoCA) and comprehensive neuropsychological evaluations.
    • Frailty assessed using Fried et al. criteria.

    Main Results:

    • Lower MoCA scores correlated with higher frailty levels (r=-0.34, P<.032).
    • Greater frailty associated with worse executive control, working memory (r²=0.267, β=-0.517, P<.011), and delayed recognition memory (r²=0.207, β=-0.455, P<.025).

    Conclusions:

    • A significant correlation exists between frailty and neuropsychological impairment.
    • Frailty may serve as an early indicator for mild cognitive impairment and dementia.