Related Experiment Video
Updated: Dec 16, 2025

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
Published on: October 15, 2018
Ion traps in modern mass spectrometry
Dirk Nolting1, Robert Malek1, Alexander Makarov1
1Thermo Fisher Scientific, Bremen, Germany.
Abstract:
This review is devoted to trapping mass spectrometry wherein ions are confined by electromagnetic fields for prolonged periods of time within limited volume, with mass measurement taking place within the same volume. Three major types of trapping mass spectrometers are discussed, specifically radiofrequency ion trap, Fourier transform ion cyclotron resonance and Orbitrap. While these three branches are intricately interwoven with each other over their recent history, they also differ greatly in their fundamentals, roots and historical origin. This diversity is reflected also in the difference of viewpoints from which each of these directions is addressed in this review. Following the theme of the issue, we focus on developments mainly associated with the country of Germany but, at the same time, we use this review as an illustration of the rapidly increasing globalization of science and expanding multi-national collaborations.
Related Concept Videos
MALDI-TOF Mass Spectrometry
Mass Spectrometry: Overview
Tandem Mass Spectrometry
Mass Analyzers: Common Types
Mass Spectrometers
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

