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Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
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Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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Ion traps in modern mass spectrometry.

Dirk Nolting1, Robert Malek1, Alexander Makarov1

  • 1Thermo Fisher Scientific, Bremen, Germany.

Mass Spectrometry Reviews
|October 31, 2017
PubMed
Summary

This review covers trapping mass spectrometry, focusing on radiofrequency ion traps, Fourier transform ion cyclotron resonance, and Orbitrap instruments. It highlights German developments and global scientific collaboration in this field.

Keywords:
Fourier transformOrbitrap analyzerhigh resolutionion trapmass accuracymass spectrometry

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Area of Science:

  • Analytical Chemistry
  • Physical Chemistry

Background:

  • Trapping mass spectrometry confines ions using electromagnetic fields for precise mass measurements within a limited volume.
  • This technique encompasses several major instrument types with distinct principles and historical origins.

Purpose of the Study:

  • To review advancements in trapping mass spectrometry, emphasizing developments originating from Germany.
  • To illustrate the globalization of scientific research and international collaborations in the field.

Main Methods:

  • Discussion of three primary trapping mass spectrometry techniques: radiofrequency ion trap, Fourier transform ion cyclotron resonance (FT-ICR), and Orbitrap.
  • Analysis of the interwoven history and fundamental differences between these methods.

Main Results:

  • Overview of the diverse approaches and historical roots within trapping mass spectrometry.
  • Highlighting the significant contributions from Germany to the field's progress.

Conclusions:

  • Trapping mass spectrometry continues to evolve, with distinct yet interconnected technological branches.
  • The field exemplifies the increasing trend of global scientific cooperation and multinational research efforts.