Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vivo imaging of central nervous system fluid spaces using synchrotron radiation-based micro computed tomography.

Nature communications·2026
Same author

Magnetic resonance imaging-based biodistribution of theranostic AGuIX nanoparticles in the NANORAD 2 clinical trial for brain metastases.

Journal of neuro-oncology·2026
Same author

Ultrasound-Based Therapies in Primary Central Nervous System Tumors.

Cancers·2026
Same author

Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography.

Intensive care medicine experimental·2026
Same author

Targeted Inhibition of mGlu5 Receptors in the Contralesional Hemisphere Improves Functional Recovery After Stroke.

Stroke·2026
Same author

Perineuronal nets in the insular cortex shape salience-related behaviour in diabetes.

Neurobiology of disease·2026

Related Experiment Video

Updated: Feb 19, 2026

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
10:58

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

Published on: September 27, 2020

5.5K

Rat sensorimotor cortex tolerance to parallel transections induced by synchrotron-generated X-ray microbeams.

Erminia Fardone1,2, Alberto Bravin3, Alfredo Conti4

  • 1European Synchrotron Radiation Facility, Grenoble, France.

Scientific Reports
|November 1, 2017
PubMed
Summary

Microbeam radiation therapy shows promise for brain tumors. Studies indicate healthy rat brain tissue tolerates microbeam irradiation, with minimal long-term effects on motor function and minimal reactive gliosis at higher doses.

More Related Videos

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex
10:42

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Published on: August 18, 2018

9.5K
Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
05:47

Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

Published on: October 22, 2016

13.0K

Related Experiment Videos

Last Updated: Feb 19, 2026

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
10:58

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

Published on: September 27, 2020

5.5K
Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex
10:42

Rodent Behavioral Testing to Assess Functional Deficits Caused by Microelectrode Implantation in the Rat Motor Cortex

Published on: August 18, 2018

9.5K
Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
05:47

Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

Published on: October 22, 2016

13.0K

Area of Science:

  • Radiology
  • Neuroscience
  • Radiation Biology

Background:

  • Microbeam radiation therapy (MRT) is an emerging preclinical technique using synchrotron X-rays for treating brain tumors and epilepsy.
  • Translating MRT to human patients necessitates a thorough understanding of its long-term radiobiological effects on healthy brain tissue.

Purpose of the Study:

  • To characterize the tolerance of the rat sensorimotor cortex to microradiosurgical parallel transections.
  • To evaluate the long-term radiobiological impact of microbeam irradiation on healthy brain tissue.

Main Methods:

  • Adult male Wistar rats were subjected to irradiation with parallel microbeams of varying thickness, spacing, and incident dose (100/600 µm thickness, 400/1200 µm spacing, 150/360 Gy dose).
  • Motor performance was assessed over a 3-month period post-irradiation.
  • Histological and immunohistochemical analyses were performed 3 months after irradiation to evaluate tissue effects.

Main Results:

  • Microbeam irradiation did not significantly affect weight gain or motor performance in rats.
  • No gross signs of paralysis or paresis were observed.
  • Cortical architecture remained unaltered, despite localized cell death. Reactive gliosis was observed at 150 Gy but not at 360 Gy.

Conclusions:

  • The rat sensorimotor cortex demonstrates tolerance to microbeam irradiation, with no significant long-term motor deficits.
  • Higher doses of microbeam irradiation (360 Gy) did not induce reactive gliosis, suggesting a potentially favorable safety profile for future clinical translation.