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Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
Published on: November 21, 2013
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Motor System Pathology in Psychosis
Sebastian Walther1, Vijay A Mittal2,3,4,5,6
1Translational Research Center, University Hospital of Psychiatry, University of Bern, Murtenstrasse 21, 3008, Bern, Switzerland. sebastian.walther@upd.unibe.ch.
Current Psychiatry Reports
|November 1, 2017
Summary
Motor abnormalities are common in psychosis across all stages. These signs, assessed through various measures, reveal insights into the brain
Area of Science:
- Neuroscience
- Psychiatry
- Movement Disorders
Background:
- Motor abnormalities are a core feature of psychosis.
- Neurological soft signs, Parkinsonism, and dyskinesia are prevalent in individuals at risk and with diagnosed psychosis.
Purpose of the Study:
- To review recent literature on motor assessments in psychosis.
- To explore the pathophysiology of motor abnormalities in psychosis.
Main Methods:
- Review of recent scientific literature.
- Analysis of instrumental measures of fine motor performance, balance, and spontaneous activity.
- Examination of neuroimaging studies on motor networks.
Main Results:
- Motor abnormalities are present in individuals at risk and across all stages of schizophrenia.
- These motor signs correlate with specific symptom dimensions and predict poorer outcomes.
- Neuroimaging reveals altered neural maturation and motor system alterations in psychosis.
Conclusions:
- Motor abnormalities offer a unique perspective on psychosis pathobiology.
- These findings have potential applications in screening, staging, and outcome prediction for psychosis.
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