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Inkjet-Printed Paper-Based Colorimetric Polyion Sensor Using a Smartphone as a Detector.

Xuewei Wang¹, Mollie Mahoney¹, Mark E Meyerhoff¹

¹Department of Chemistry, University of Michigan , Ann Arbor, Michigan 48109-1055, United States.

Analytical Chemistry

|November 1, 2017

Summary

Researchers developed novel paper-based sensors for detecting polyions. These sensors, utilizing simple colorimetric changes analyzed by a smartphone, offer a sensitive and accessible method for biological and chemical analysis.

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Area of Science:

Analytical Chemistry
Biosensing Technology
Materials Science

Background:

Optodes are sensor devices that change color in response to specific analytes.
Existing optode technologies often require plasticizers or complex fabrication processes.
There is a need for simple, cost-effective, and sensitive detection methods for polyions.

Purpose of the Study:

To report the first paper-based polyion-sensitive optodes.
To develop a plasticizer-free sensing platform for polycations and polyanions.
To demonstrate the application of these optodes in detecting biological molecules and substances in complex samples.

Main Methods:

Fabrication of paper-based optodes by printing dinonylnaphthalene sulfonic acid and chromoionophore I onto filter paper.
Utilizing cooperative ion pair formation between polycations and the ion exchanger for selective sensing.
Colorimetric analysis of optode response using a smartphone camera and application.
Development of a multilayer device for simplified indirect detection of protease activity and polyanions.
Demonstration of pentosan polysulfate detection in undiluted urine samples.

Main Results:

The paper-based optodes showed sensitive colorimetric responses to polycations like protamine, but not to small inorganic cations.
The system enabled indirect detection of protease activity (trypsin) and polyanions (pentosan polysulfate, heparin).
A simplified multilayer device successfully detected pentosan polysulfate in urine.
Plasticizer-free polyanion-sensitive optodes were successfully fabricated on cellulose paper strips.

Conclusions:

Paper-based, plasticizer-free optodes offer a sensitive and versatile platform for polyion detection.
Smartphone-based analysis enables simple and accessible quantification of analytes.
This technology holds promise for point-of-care diagnostics and environmental monitoring.