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Updated: Feb 19, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Vitamin D receptor-binding site variants affect prostate cancer progression
Victor C Lin1,2, Shu-Pin Huang3,4,4, Huei-Ju Ting5
1Department of Urology, E-Da Hospital, Kaohsiung 824, Taiwan.
Specific gene variants in vitamin D receptor (VDR) binding sites may predict prostate cancer progression. HFE and TUSC3 gene expression levels influence cancer cell behavior and patient outcomes.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Vitamin D modulates cellular proliferation via the vitamin D receptor (VDR).
- VDR binds to DNA in target gene regulatory sequences.
- Prostate cancer progression may be influenced by genetic variations in VDR-binding sites.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in VDR-binding sites and prostate cancer progression.
- To identify potential prognostic markers and susceptibility genes for prostate cancer.
Main Methods:
- Genome-wide prediction database used to select 62 SNPs in VDR-binding sites.
- Genotyping performed in 515 prostate cancer patients and replicated in 411 patients.
- Prognostic significance assessed using Kaplan-Meier analysis and Cox regression models.
Main Results:
- HFE rs9393682 associated with localized prostate cancer progression.
- TUSC3 rs1378033 associated with advanced prostate cancer progression.
- Vitamin D affected HFE and TUSC3 expression, impacting cancer cell proliferation, migration, and wound healing.
Conclusions:
- Common variants in VDR-binding sites can serve as prognostic markers for prostate cancer.
- HFE and TUSC3 are identified as plausible susceptibility genes for prostate cancer.
- Further studies with larger cohorts are warranted.
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