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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer

Rongwei Guan1, Lei Peng2, Dong Wang2

  • 1Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China.

Oncotarget
|November 2, 2017
PubMed

Insights

Decreased TOB1 expression and increased nuclear TOB1 phosphorylation are linked to aggressive gastric cancer (GC) and poor prognosis. TOB1 nuclear retention is crucial for inhibiting GC cell proliferation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • TOB1, a BTG/TOB family member, inhibits tumor cell proliferation.
  • Previous studies noted TOB1 down-regulation and phosphorylation in gastric cancer (GC).

Purpose of the Study:

  • To investigate the subcellular distribution and clinical significance of TOB1 expression and phosphorylation in GC.
  • To determine the prognostic value of TOB1 in gastric cancer.

Main Methods:

  • Immunohistochemical analysis of 341 primary GC and normal gastric tissues.
  • Assessment of TOB1 expression, nuclear TOB1 phosphorylation, and correlation with clinicopathological features and survival.
  • Analysis of TOB1's role in GC cell proliferation, migration, and invasion via overexpression studies.

Main Results:

  • GC tissues showed lower nuclear TOB1 expression and higher nuclear TOB1 phosphorylation compared to normal tissues.
  • Decreased nuclear TOB1 expression correlated with advanced TNM stage.
  • Increased nuclear TOB1 phosphorylation was associated with poor differentiation, high TNM stage, and reduced overall survival in intestinal type GC.
  • Nuclear TOB1 concentration was an independent prognostic factor for intestinal type GC.
  • TOB1 nuclear retention inhibited GC cell proliferation, migration, and invasion.

Conclusions:

  • Decreased TOB1 expression and increased nuclear TOB1 phosphorylation are associated with aggressive tumor behavior and poor prognosis in intestinal type GC.
  • Nuclear TOB1 retention is critical for its anti-proliferative activity in gastric cancer.
Keywords:
TOB-1anti-proliferative activitygastric cancerp-TOB1subcellular localization

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