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Paraoxonase 1 Activity, Lipid Profile, and Atherogenic Indexes Status in Coronary Heart Disease

Mostafa Cheraghi1, Gholamreza Shahsavari2, Ali Maleki1

  • 1Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Reports of Biochemistry & Molecular Biology
|November 2, 2017
PubMed

Insights

Coronary heart disease (CHD) patients exhibit higher lipid levels and atherogenic indexes, alongside lower paraoxonase 1 (PON1) activity and high-density lipoprotein cholesterol (HDL-C). These findings highlight key biomarkers for CHD risk assessment and management.

Area of Science:

  • Biochemistry
  • Cardiology
  • Clinical Medicine

Background:

  • Dyslipidemia is a significant independent risk factor for coronary heart disease (CHD).
  • Paraoxonase 1 (PON1) activity and lipid profiles are crucial in cardiovascular health.
  • Atherogenic indexes provide insights into cardiovascular risk.

Purpose of the Study:

  • To compare paraoxonase 1 (PON1) activity, lipid profiles, and atherogenic indexes between coronary heart disease (CHD) patients and healthy controls.
  • To investigate the relationship between PON1 activity, high-density lipoprotein cholesterol (HDL-C), and atherogenic indexes in CHD patients.

Main Methods:

  • A case-control study involving 50 CHD patients and 50 matched healthy controls.
  • Analysis of serum PON1 activity, triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), HDL-C, and fasting blood glucose (FBG).
  • Statistical analysis using unpaired Student's t tests and Pearson's correlation analysis.

Main Results:

  • CHD patients showed significantly higher levels of TG, TC, LDL, VLDL, FBG, and atherogenic indexes compared to controls.
  • Significantly lower PON1 activity and HDL-C levels were observed in CHD patients.
  • PON1 activity positively correlated with HDL-C and negatively with atherogenic coefficients and cardiac risk ratios in CHD patients.

Conclusions:

  • Coronary heart disease is strongly associated with elevated lipid levels, increased atherogenic indexes, and diminished PON1 activity and HDL-C concentrations.
  • These biochemical markers are pivotal in understanding CHD pathophysiology.
  • Effective management of CHD necessitates addressing lipid abnormalities and potentially augmenting PON1 activity or HDL-C levels.
Abstract

Keywords:
Atherogenic indexCoronary heart diseaseLipid profileParaoxonase 1 activity

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