Related Experiment Video
Updated: Feb 19, 2026
07:27
How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
Published on: August 19, 2020
12.6K
Oxidation Reduction Potential (ORP) is Predictive of Complications Following Pediatric Cardiac Surgery
Amy E Schmidt1, Emily Gore2, Kelly F Henrichs2
1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Box 608, Rochester, NY, 14642, USA. Amy_Schmidt@urmc.rochester.edu.
Pediatric Cardiology
|November 2, 2017
Summary
Lower oxidation reduction potential (ORP) in pediatric cardiac surgery patients indicates a higher risk of complications and poor outcomes. Higher preoperative haptoglobin levels may protect against these adverse effects.
Area of Science:
- Biochemistry
- Pediatric Cardiology
- Critical Care Medicine
Background:
- Oxidation reduction potential (ORP) reflects the balance between oxidizers and reducers in biological systems.
- Oxidative stress (OS) plays a critical role in cellular injury, immune response, and disease regulation.
- Cardiopulmonary bypass (CPB) is a complex procedure in pediatric cardiac surgery that can impact the redox system.
Purpose of the Study:
- To investigate the association between changes in the redox system, specifically ORP, and patient outcomes following cardiopulmonary bypass in pediatric cardiac surgery.
- To identify potential biomarkers that indicate redox imbalance and predict post-operative complications.
Main Methods:
- Analysis of 664 plasma samples from 162 pediatric patients undergoing cardiac surgery with varying CPB durations.
- Measurement of ORP levels at different time points, including preoperatively and at 6 and 12 hours post-CPB.
- Correlation of ORP values with clinical outcomes such as survival rate, thrombotic complications, infections, and overall post-operative complications.
Main Results:
- Lower ORP values at 12 hours post-CPB were significantly associated with a poorer survival rate (p=0.005) and a higher incidence of thrombotic complications (p<0.008).
- Patients who developed infections showed lower ORP levels at 6 (p=0.02) and 12 hours (p=0.004) post-CPB.
- A significant association was found between lower ORP levels at 6 and 12 hours post-CPB and the development of any post-operative complication (p=0.002 and p=0.0007, respectively).
- Free hemoglobin, IL-6, IL-10, and CRP levels were not correlated with ORP.
- Higher preoperative haptoglobin levels were found to be protective against decreases in ORP.
Conclusions:
- Decreased ORP serves as a marker for poor outcomes and predicts post-operative complications like thrombosis and infection in critically ill pediatric cardiac surgery patients.
- Redox imbalance and OS may contribute to the risk of complications and adverse outcomes in pediatric patients undergoing CPB.
- Haptoglobin may represent a potential biomarker for increased resilience to OS in this patient population.
Related Concept Videos
01:30Ladder Diagrams: Redox Equilibria
816
Ladder diagrams are useful tools for understanding redox equilibrium reactions, especially the effects of concentration changes on the electrochemical potential of the reaction. The vertical axis in the redox ladder diagrams represents the electrochemical potential, E. The area of predominance is demarcated using the Nernst equation.
Consider the Fe3+/Fe2+ half-reaction, which has a standard-state potential of +0.771 V. At potentials more positive than +0.771 V, Fe3+ predominates, whereas Fe2+...
Consider the Fe3+/Fe2+ half-reaction, which has a standard-state potential of +0.771 V. At potentials more positive than +0.771 V, Fe3+ predominates, whereas Fe2+...
816
01:23Redox Equilibria: Overview
1.6K
A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
1.6K
01:24Redox Reactions
59.0K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
59.0K
01:27Redox Reactions
1.2K
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
1.2K
03:02Standard Electrode Potentials
50.7K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.7K
03:11Oxidation-Reduction Reactions
76.1K
Oxidation–Reduction Reactions
76.1K