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Related Experiment Video

Updated: Feb 19, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
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Quinoxalinone as a Privileged Platform in Drug Development.

Leilei Shi1, Wei Hu2, Jifeng Wu3

  • 1Key Laboratory of Chemistry and Chemical Biology (Ministry of Education), Department of Pharmaceutical Science, College of Pharmacy, Shandong University, Jinan, China.

Mini Reviews in Medicinal Chemistry
|November 2, 2017
PubMed
Summary

Quinoxalinone derivatives are vital nitrogen-containing heterocycles with diverse pharmaceutical applications. This review highlights recent advancements in their synthesis, biological activities, and structure-activity relationships for drug discovery.

Keywords:
Binding modeSAR analysis.biological activitiesderivatesquinoxalinequinoxalinone skeleton

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Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Quinoxalinone (quinoxalin-2-one) is a key nitrogen-containing heterocyclic scaffold.
  • This core structure is present in numerous pharmacologically active compounds.
  • Many quinoxalinone derivatives have advanced into clinical trials, underscoring their therapeutic potential.

Purpose of the Study:

  • To review recent developments in quinoxalinone derivatives.
  • To emphasize their diverse biological applications.
  • To analyze structure-activity relationships of novel quinoxalinone analogues.

Main Methods:

  • Literature review focusing on recent years.
  • Analysis of synthetic strategies for quinoxalinone derivatives.
  • Evaluation of biological activities and structure-activity relationships.

Main Results:

  • Identification of newly emerged quinoxalinone-based derivatives.
  • Compilation of their significant biological applications.
  • Summary of structure-activity analyses.

Conclusions:

  • Quinoxalinone scaffold offers significant synthetic versatility.
  • Ongoing research continues to uncover novel bioactive derivatives.
  • Structure-activity relationship studies guide the development of new therapeutics.