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Updated: Feb 19, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

Staggered trap arrays for robust microfluidic sample digitization.

A J Sposito¹, D L DeVoe

¹Department of Mechanical Engineering, University of Maryland, College Park, MD, USA. ddev@umd.edu.

|November 2, 2017

Summary

This summary is machine-generated.

This study introduces a novel microfluidic trap design for reliable sample digitization. The staggered array ensures efficient sample loading and discretization, simplifying workflows with low-cost materials.

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Last Updated: Feb 19, 2026

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Area of Science:

Microfluidics
Biotechnology
Materials Science

Background:

Microfluidic devices are crucial for biological sample analysis.
Achieving reliable sample digitization in microfluidic traps can be challenging, especially with non-gas-permeable materials.

Purpose of the Study:

To present a novel sample digitization method using staggered microfluidic traps.
To enable reliable sample filling and discretization in high aspect ratio microwells.

Main Methods:

Exploiting controlled fluid pinning at geometric discontinuities.
Developing a geometric model to predict filling and discretization.
Experimentally validating the model with cyclic olefin polymer devices.

Main Results:

Demonstrated a 768-element staggered trap array.
Achieved reliable passive loading and discretization within 5 minutes.
Validated the impact of device geometry on sample filling.

Conclusions:

The staggered trap design facilitates reliable sample digitization.
This platform offers a simplified workflow, flexible design, and repeatable operation.
Low-cost thermoplastic substrates can be effectively utilized.