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Immunohistochemical Changes of the Transcription Regulatory Factors in Rat Striatum after Methamphetamine
Tatsuyuki Muratake1, Kazuhiko Toyooka1, Shigenobu Hayashi1
1Department of Psychiatry, Niigata University School of Medicine, Niigata City 951-8510, JapanNational Saigata Hospital, Ogata Town, Nakakubikigun, Niigata Prefecture 949-3193, JapanDepartment of Molecular Neuropathology, Brain Research Institute, Niigata University, Niigata City 951-8585, Japan.
Abstract:
We have found evidence for cyclic adenosine monophosphate (cAMP) response element (CRE) in the 5'-upstream region of the human 14.3.3 η chain gene during studies on isolation and structure of animal brain 14.3.3 cDNA and the human 14.3.3 h chain gene. cAMP response element-binding protein (CREB) and phosphorylated CREB (pCREB) may bind to this CRE. Since it was considered that these CREBs may play an important role in molecular mechanisms in the brain of animals treated with methamphetamine, we examined the expression of CREB and pCREB in rat brain after acute and chronic methamphetamine administrations using antibodies against CREB and pCREB. We observed findings for change in the expression of these factors. Our findings should be discussed in relation to the data of other authors.
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