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Response to cimetidine in a 1-year-old child with PFAPA syndrome

Kazuto Taniguchi1, Nobuyasu Ono2, Tatsuya Sakai1

  • 1Cho-ritsu Tara Hospital, Tara, Saga, Japan.

The Turkish Journal of Pediatrics
|November 2, 2017
PubMed

Insights

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome can be managed with cimetidine to reduce febrile attacks. This may be a useful interim treatment until tonsillectomy is a safer option for children.

Area of Science:

  • Pediatrics
  • Immunology
  • Otolaryngology

Background:

  • Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome presents with recurrent febrile episodes.
  • Tonsillectomy is an established treatment, but its suitability varies with age.
  • The efficacy of cimetidine for PFAPA syndrome remains debated.

Purpose of the Study:

  • To evaluate the effectiveness of cimetidine in managing PFAPA syndrome.
  • To present case studies illustrating treatment outcomes.
  • To explore cimetidine as a potential bridge therapy before tonsillectomy.

Main Methods:

  • Case report of a 1-year-old girl treated with cimetidine.
  • Case report of a 6-year-old boy who underwent tonsillectomy.
  • Clinical observation of symptom reduction and treatment success.

Main Results:

  • Cimetidine treatment in a pediatric patient led to a reduction in febrile attacks.
  • Successful tonsillectomy was performed in an older pediatric patient.
  • Both interventions showed positive outcomes for PFAPA syndrome management.

Conclusions:

  • Cimetidine may effectively reduce febrile episodes in PFAPA syndrome.
  • This treatment can be considered until tonsillectomy is age-appropriate.
  • Further research is warranted to confirm cimetidine's role in PFAPA management.

Keywords:
PFAPA syndromecimetidinefebrile attackstonsillectomy

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