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Updated: Feb 8, 2026

Single Sensillum Recordings for Locust Palp Sensilla Basiconica
Published on: June 23, 2018
Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete
Shi Ying Ma1, Yong Sheng Xiao1, Bo Zhang1
1State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University , Nanjing 210023, China.
Abstract:
Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.
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