Canustatins A and B, Two Polyketides from Streptomyces canus NA07887
Hao Guo1, Zi Jian Jiang1, Xing Yi Wang2
1State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Department of Neurology, Nanjing Drum Tower Hospital, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
None:
Canustatins A and B, two structurally novel polyketide metabolites, were isolated from the actinobacterium Streptomyces canus NA07887. Their structures were determined through comprehensive spectroscopic analysis, including NMR and HRESIMS, combined with the comparison of experimental and theoretical electronic circular dichroism (ECD) spectra. Canustatin A features an unprecedented 3,6-dioxabicyclo[3.1.0]hexane moiety, a structural motif rarely encountered in type I polyketides. Stable isotope labeling studies facilitated the proposal of a plausible biosynthetic pathway for these compounds. In addition, canustatin A exhibited moderate antibacterial activity against multidrug-resistant Acinetobacter baumannii ATCC AYE.
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