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Deep penetrating nevus.

J A Seab1, J H Graham, E B Helwig

  • 1Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000.

The American Journal of Surgical Pathology
|January 1, 1989
PubMed
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Deep penetrating nevus (DPN) is a benign melanocytic lesion that can mimic malignant melanoma. Histologic differentiation is crucial, as DPN shows no recurrence or metastasis despite initial misdiagnosis.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Deep penetrating nevus (DPN) is a rare melanocytic neoplasm.
  • DPN can be challenging to distinguish from malignant melanoma on initial histologic examination.

Purpose of the Study:

  • To present a clinical and histologic study of DPN.
  • To emphasize the importance of differentiating DPN from malignant melanoma and other nevi.

Main Methods:

  • Clinical and histologic evaluation of 70 patients with DPN.
  • Long-term follow-up of 48 patients.

Main Results:

  • DPN lesions are typically darkly pigmented, found on the face, trunk, or extremities of young adults (10-30 years).
  • Histologically, DPN features loosely organized nests of pleomorphic pigmented cells penetrating deep into the dermis and subcutaneous fat.

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  • Despite 29% of cases initially being misdiagnosed as malignant melanoma, no local recurrences or distant metastases were observed in 48 patients with up to 23 years of follow-up.

    • Conclusions:

    • DPN is a benign entity that requires careful histologic differentiation from malignant melanoma.
    • Characteristic histologic features aid in distinguishing DPN from other melanocytic nevi.