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Updated: Feb 19, 2026

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
Published on: February 21, 2014
Droplet Formation by Rupture of Vibration-Induced Interfacial Fingers
Sze Yi Mak1,2, Youchuang Chao1,2, Shakurur Rahman1
1Department of Mechanical Engineering, The University of Hong Kong , Pok Fu Lam 999077, Hong Kong.
Abstract:
By imposing vibration to a core-annular flow of an aqueous two-phase system (ATPS) with ultralow interfacial tension, we observe a liquid finger protruding from the interface of an expanding jet. We find that the protruded finger breaks up only when its length-to-width ratio exceeds a threshold value. The breakup follows a constant wavelength-to-width ratio that is consistent with that of breakup under Rayleigh-Plateau instability. The mechanism is applicable to aqueous two-phase systems with a large range of viscosity ratios. The protruded finger can break up into small droplets that are monodisperse in size, controllable in generation frequency under a wide range of flow rates. This work suggests a way to generate small water-water droplets with high monodispersity and production rate from a single nozzle.
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