Efficient extraction method using magnetic carbon nanotubes to analyze cocaine and benzoylecgonine in breast milk by
Rosimeire Resende Dos Santos1, Maria José Nunes Paiva2, Júlio César Veloso2
1Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte; Brasil, MG, 31270-901, Brazil.
Aim:
The increasing use of cocaine (COC) during breastfeeding has led to growing concern about exposure of infants. Therefore, to study this exposure, a new method to analyze COC and benzoylecgonine in breast milk was developed.
Methodology:
A new extraction method was used for the first time to analyze COC and its major metabolite, benzoylecgonine, in breast milk using magnetic carbon nanotubes partially doped with nitrogen.
Results:
The calibration curves were linear in the range 5.0-180.0 ng ml-1. The limit of quantification was 5.0 ng ml-1. Coefficients of variation were between 3.2 and 13.9%. Recovery was between 89.6 and 99.2%.
Conclusion:
The proposed method is simple, efficient and suitable to determine analytes in breast milk.
