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Eccrine-Centric Melanocytic Nevus.
Raymond M Fertig1, Adar Berghoff2, Jessica Cervantes1
1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.
The American Journal of Dermatopathology
|November 3, 2017
Summary
A novel benign melanocytic nevus pattern, the eccrine-centric melanocytic nevus, is described. This rare presentation mimics metastatic disease, emphasizing the need for accurate histopathologic diagnosis in pigmented lesions.
Area of Science:
- Dermatopathology
- Histopathology
- Oncology
Background:
- Benign melanocytic neoplasms exhibit diverse histopathologic patterns.
- Accurate diagnosis relies on recognizing these patterns.
- Distinguishing benign from malignant pigmented lesions is crucial.
Observation:
- A 50-year-old African American woman presented with a rapidly growing mole on her foot.
- Histopathologic examination revealed a unique pattern of melanocytic nevus.
- The lesion displayed increased eccrine gland density with melanocytes exclusively in a peri-eccrine distribution.
Findings:
- The described lesion is an eccrine-centric melanocytic nevus, a previously unreported low-power architectural pattern.
- Melanocytes were densely pigmented and located solely around eccrine gland ducts.
- No atypical features suggestive of malignancy were observed.
Implications:
- This distinctive pattern, while benign, can be mistaken for metastatic disease due to well-delineated dermal nests.
- Recognition of this eccrine-centric pattern is vital for accurate diagnosis and avoiding misclassification.
- Understanding rare melanocytic nevus presentations enhances diagnostic capabilities in pigmented lesion evaluation.
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