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Laser-Assisted and Device-Assisted Filler Delivery: A Histologic Evaluation.

Jessica Cervantes1, Yu-Feng Chang2, Jeffrey S Dover3,4

  • 1Harvard Combined Dermatology Residency Training Program, Boston, Massachusetts.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]
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PubMed
Summary
This summary is machine-generated.

Fractional CO2 laser with poly-L-lactic acid (PLLA) showed the best transcutaneous filler delivery. Other devices like microneedling and fractional radiofrequency microneedling (FRMN) were less effective for enhancing filler absorption.

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Area of Science:

  • Dermatology and Aesthetic Medicine
  • Biomedical Engineering
  • Histology and Tissue Analysis

Background:

  • Transcutaneous delivery of cosmetic fillers is often enhanced using lasers and other devices.
  • Limited histologic data exists on the efficacy of various laser/device-assisted filler delivery methods.
  • Optimal device and filler combinations for enhanced delivery require further investigation.

Purpose of the Study:

  • To objectively evaluate the histological effects of laser-assisted and device-assisted filler delivery.
  • To compare the efficacy of different energy-based devices in enhancing transcutaneous filler penetration.
  • To identify the most effective combination of devices and fillers for improved delivery.

Main Methods:

  • Ex vivo human abdominoplasty skin samples were utilized for the study.
  • Treatments included fractional CO2 laser, fractional radiofrequency microneedling (FRMN), and microneedling.
  • Topical application of poly-L-lactic acid (PLLA), hyaluronic acid, calcium hydroxylapatite, and tissue marking dye followed treatment, with subsequent histologic evaluation.

Main Results:

  • Fractional CO2 laser demonstrated significant channel formation and delivery of PLLA and black dye, with lesser amounts of hyaluronic acid and minimal calcium hydroxylapatite.
  • Microneedling effectively delivered only black dye.
  • FRMN showed no significant channel formation or product delivery.

Conclusions:

  • Fractional CO2 laser combined with PLLA is the most effective method for laser/device-assisted filler delivery among the tested modalities.
  • Neither microneedling nor FRMN proved effective in enhancing filler delivery in this study.
  • Further research into optimizing laser and filler parameters for transcutaneous delivery is warranted.